The Inner Lab
The Inner Lab
The Skin Longevity Guide
A short guide to caring for your skin, and yourself, over time.
From the co-founder of Skin Diligent · Written by Tule Park
A note before we begin
How much of the way we age is truly ours to shape?
For most of history, the answer was almost none. Aging was fate, written in our genes, decided before we were born. The science of the last two decades has changed that. Our biology is not a fixed sentence. It is more like a conversation, still going on, and we have more say in it than anyone once thought. This is the heart of epigenetics, an extremely empowering science.
The skin is where that conversation shows. It is easy to treat skin as a surface to be corrected and covered. It is truer to see it as part of the whole body, shaped by our hormones, our sleep, our stress, and by time. Nothing in the skin stands alone. Caring for it is rarely only about the skin.
What follows sets out a few of these ideas in plain language. I have tried to be honest about what the science has shown, what it is now proving wrong, and what it still has to prove. At the end there is a thought about what I believe longevity means. It is a personal understanding, one that took me years, and one that I think will keep evolving. When you reach the end, I would love to hear what you think.
One
Are we obsessed with looking younger?
Almost all of skincare is about looking younger. Turning back time. This guide wants something different, and in the end more useful. It is about aging well, not erasing age. Skin that is healthy across a whole life. Skin that feels good now, stays resilient over the years, and keeps doing its work. That is what we mean by skin longevity.
It comes down to one idea. Skin is not fixed. It responds to sunlight and sleep, to stress, to what we eat, to what we put on it, and most of all to time. Some of these age it faster. Others help it hold. Longevity is simply the patient work of choosing more of the second kind, in small ways that add up.
We cannot talk about keeping skin healthy without asking what we put on it.
Two
The other 95 percent of your skincare
When a skincare product names a hero ingredient, that ingredient is rarely more than 1 to 5 percent of what is inside. The other 95 percent is everything else: the base, the texture, the preservatives that hold it together. Most of the industry perfects the small, famous part and pays little attention to the rest.
We go further. We study the hero ingredient and the whole formula around it.
95%
of a formula is everything other than the named active.
Every ingredient in a Skin Diligent formula has to earn its place, the quiet 95 percent most of all. Your skin does not read the label. It meets the whole formula. This is the least glamorous work we do, and I think it is the work that matters.
Three
Is your skincare safe for your hormones?
Nothing we do means more to me than this.
This began at home, with a worry about someone I love. Our first formula was made for skin prone to blemishes. Most of the people who needed our products were women and young people, the two groups with the most hormone fluctuation. Women, through the monthly cycles that shape their health and their mood. Young people, through the surge of puberty that drives their growth, from height to the reproductive system. A question took hold of me and would not let go. Could a product meant to help be disturbing the hormones that run our systems? Almost no one was asking this. So we went looking for the answer.
What I found surprised me. Almost no one tests for this, not the finished products and not the ingredients. So we decided to test the products ourselves, in our own lab.
Tested, not claimed
Tested free of estrogenic and androgenic endocrine disruptionThe whole finished product, not one ingredient in isolation.
In the form it reaches you. The wording is exact, and we chose it with care.
Four
Why does skin age?
People who study aging have traced it to 14 underlying processes, the shared roots the visible signs grow from1.Note 1López-Otín et al., Hallmarks of aging: an expanding universe. Cell, 2023. Full reference The skin shows them early, because it sits at the border between us and the world.
Most skincare treats the symptoms, the lines and wrinkles on the surface. The industry calls this anti-aging. We wanted to understand something else. Why skin ages at all. That question is what guides what we put in a formula.
Underneath it all sits one word. Epigenetics. It sounds difficult. The idea is simple. If your genes are the text, epigenetics decides which lines get read, and how often. That reading changes with age, with your surroundings, and with the choices you make each day. It is where biology, environment, and time meet. It is why two people the same age can age so differently.
Hormones matter here too. The chemicals that disturb them are now understood to work as epigenetic signals, changing how your genes are read2.Note 2Gore et al., EDC-2, the Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocrine Reviews, 2015. Full reference We have been testing every finished formula free of estrogenic and androgenic endocrine disruption since 2021. Although we started out of concern for women and young people, the science has since shown that endocrine disruption spares no one. Hormone safety is now everyone's concern.
Five
Day and night: your skin's circadian rhythm
Your skin runs on a daily clock, its circadian rhythm, the same one that runs the rest of the body. In daylight it works outward, protecting itself against sun and pollution. After dark it turns inward, to recovery. We built the range in two halves, so it works with that rhythm, not against it.
Morning
The morning system is for protection and light. At its heart, two serums. The Vitamin C Serum-in-Oil, which helps skin look bright and defended through the day, and the Cellular Hydration Serum.
Two steps in the morning, two at night. Each one is part of a system. None works alone.
Six
Daily habits that help your skin
Skincare is only part of the story. A few ordinary habits do a surprising amount of the work, and they cost nothing. Here are a few I have tested on myself and made my own.
The sun, with some nuance
The sun is not the enemy it is made out to be. The body needs it. Morning light helps set your internal clock4, and with it your sleep and your energy.Note 4Blume, Garbazza & Spitschan on light, circadian rhythms, sleep and mood. Somnologie, 2019. Full reference We were never meant to hide from it completely.
And yet the same sun, taken carelessly, does a great deal of the visible aging of skin. One study linked as much as 80 percent of the visible signs of facial aging to sun exposure3.Note 3Flament et al. put ultraviolet exposure behind as much as 80 % of visible facial aging signs. Clin Cosmet Investig Dermatol, 2013. Full reference Both things are true. So the answer is not more sun, or less, but the right sun.
Sleep, made easier
A lot of the skin's recovery happens while you sleep, so a short night is a short recovery. If falling asleep is the hard part, a few things help.
A lighter dinner, so your body is not still working when it should be winding down. A cool room, since we sleep better a little cold than a little warm. Real darkness, from heavy curtains or a simple eye mask. And some small signal, your own, that tells your body the day is over.
Skincare, and unlearning some of it
Some of what we were all taught is worth questioning, gently, on your own terms, especially in the light of the new science on skin cells.
That you must exfoliate on a schedule, whatever your skin is actually asking for. That dry skin needs a thick balm on top. That you must wash your face twice a day, or double cleanse every time. None of these are rules. As the science grows, they look more like marketing habits than real evidence. For many people they are simply too much. More products and stricter routines are not the same as more care.
One distinction is worth learning, because it changes what you buy.Worth knowingHydration is water within the skin. Moisturization is what keeps it there. Not the same thing. Hydration and moisturization are not the same. Hydration is the water in your skin. Moisturization is what keeps that water from leaving. Many people reach for a rich cream when their skin actually wants water and comfort, not weight.
Drink water, of course. Though you may find, as I have, that water alone does not fix a certain dryness. When my lips stay dry no matter how much I drink, a week of electrolytes usually settles it, and then I stop. The better idea is to listen to what your body is asking for. It tells you, all the time, in what you see and what you feel.
Seven
What longevity really means
Like many people drawn to longevity science, and to biohacking, I believed longevity had to be measured before it could be achieved. So I spent years studying the numbers and what they mean. Biomarkers. The gap between my age on paper and my biological age. All the figures that promise to tell you how well you are aging.
I have been invited to speak at longevity conferences, and I study aging closely through our own laboratory research. What I have come to see is that we are only at the dawn of something much bigger. We do not have all the answers yet. There are still many gaps in our understanding of how we age. What we do have is promising, and one day I may set those gaps out in a Journal of their own. For now, one thing seems clear. The biomarkers are only a small part of longevity.
We are quick to credit the food. The long lived villages of the Mediterranean, and their famous diet. But look closer, and something else appears. Those same people meet in the square every evening to play cards. They know their neighbors by name. Someone checks on the oldest person in town each day, without being asked. The company may count as much as the food. And the evidence that close relationships go with longer life is real, and strong5.Note 5Holt-Lunstad, Smith & Layton, meta-analysis of social relationships and mortality risk. PLoS Medicine, 2010. Full reference
Take Bryan Johnson, who has chased longevity harder than almost anyone. Always measuring. A hundred pills a day. Up before dawn, asleep by early evening. Will such a strict regimen get him to a hundred? On its own, I doubt it. But his odds are better than the numbers suggest, because he has found love, and with it, company.
So here is what I have come to believe. Longevity is not a scoreboard of markers in your blood. Those have their place. But a long and good life is not won in a lab report.
To me, longevity is peace of mind. It is reaching for happiness, and helping the people around us reach it too.
This is my conclusion so far. Your skin is part of that life, not separate from it. Care for it well, and gently. And when you are done here, close the guide and call someone you love.
I would love to know what longevity means to you.
Eight
How to begin, and what to expect
When you feel ready to begin with us, start with a system, not a single product. A morning step and an evening one, over a few unhurried weeks, will tell you more than anything you read here.
Two kinds of people usually come to us. The first weeks feel a little different for each.
If your routine is already simple
The change will be easy. The textures are light. You will notice how they feel, and how your skin feels with them.
If you are coming from more
Be patient at the start. Maybe you have exfoliated a lot, washed your face too often, or piled rich creams on dry skin because that is what you were told. Your skin may be dry, or easily upset, and it may need time to settle. Think of it as a reset. Less is asked of the skin, and it is allowed to find its balance. Give it that time, and it will repay you. We have a name for this at Skin Diligent. We call it Cellular Fitness, the patient work of keeping skin well.
Welcome. I am glad you are here.
Tule ParkCo-founder
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Peer-reviewed publications and recognized scientific organizations.
1López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243-278. Updates the original, The Hallmarks of Aging, Cell. 2013;153(6):1194-1217.
2Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocrine Reviews. 2015;36(6):E1-E150.
3Flament F, Bazin R, Laquieze S, Rubert V, Simonpietri E, Piot B. Effect of the sun on visible clinical signs of aging in Caucasian skin. Clinical, Cosmetic and Investigational Dermatology. 2013;6:221-232.
4Blume C, Garbazza C, Spitschan M. Effects of light on human circadian rhythms, sleep and mood. Somnologie. 2019;23(3):147-156.
5Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Medicine. 2010;7(7):e1000316.